In this blog, we explain how BRCA mutations affect men, what cancers are associated with them, why genetic testing for men matters, and how families can benefit from early detection.
Understanding BRCA Mutations in Men
The BRCA1 and BRCA2 genes play a vital role in repairing DNA and preventing cancer. Mutations in these genes impair this function, leading to a higher risk of developing cancer.
Both men and women inherit BRCA mutations equally from their parents. That means if your mother or father carries a BRCA mutation, you have a 50% chance of inheriting it, regardless of your gender.
Cancer Risks for Men with BRCA Mutations
Men with a BRCA2 mutation have a particularly elevated cancer risk. While BRCA1 mutations also carry risks, BRCA2 is more strongly associated with male cancers.
| Cancer Type | General Male Risk | Risk with BRCA Mutation |
|---|---|---|
| Breast Cancer (Men) | ~0.1% | Up to 8% (BRCA2) |
| Prostate Cancer | Common | Earlier onset, aggressive form |
| Pancreatic Cancer | Rare | Increased risk |
| Melanoma | Variable | Elevated with BRCA2 |
BRCA-positive men are also at risk of passing the mutation to their children.
Should Men Get BRCA Genetic Testing?
Yes, especially if they meet any of the following criteria:
- A personal or family history of breast, prostate, or pancreatic cancer
- A relative diagnosed with cancer before age 50
- Known BRCA mutation in the family
- Ashkenazi Jewish heritage (higher prevalence of BRCA mutations)
BRCA testing is typically done through a blood or saliva sample, and results are available within 2–3 weeks.
Why BRCA Testing in Men Matters
1. Early Detection Saves Lives
Men with BRCA mutations can opt for regular screening, especially for prostate and pancreatic cancers, which may help detect cancer early when it’s more treatable.
2. Family Impact
Men who carry BRCA mutations can pass them on to their children. Knowing your BRCA status enables cascade testing for family members, empowering them with life-saving information.
3. Better Health Planning
Men can take steps to monitor and manage cancer risk with:
- Annual prostate-specific antigen (PSA) tests
- Breast exams and imaging (if needed)
- Regular skin checks for melanoma
- Lifestyle adjustments to support overall health
BRCA Testing for Men at NM Medical
At NM Medical, we make BRCA testing accessible and affordable:
- Available in Mumbai, Pune, Bangalore, and Nashik
- Accredited labs (CAP & NABL-certified)
- Support from trained genetic counselors
- Option for family member testing packages
Key Takeaways for Men and Families
- Yes, men can have BRCA mutations.
- BRCA-positive men face a higher risk of prostate, male breast, and pancreatic cancer.
- Genetic testing is recommended if there’s a family history of cancer.
- Knowing your status helps protect your children and siblings.
- NM Medical offers comprehensive testing and counseling support.
Next Steps
If you’re a man with a family history of cancer, or just want peace of mind, consider BRCA genetic testing. Understanding your genetic risk is the first step toward preventive healthcare for you and your family.
