Prenatal screening tests are crucial tools that help detect the risk of chromosomal abnormalities in a developing baby. Two of the most commonly recommended tests are the NIPT (Non-Invasive Prenatal Test) and the Double Marker Test. But which one is better, more accurate, and safer?
In this article, we break down the differences between NIPT and Double Marker, so you can make an informed decision for your pregnancy, with guidance from NM Medical, one of India’s most trusted diagnostic centers.
What is the Double Marker Test?
The Double Marker Test is a first-trimester screening done between 11 and 14 weeks of pregnancy. It involves a blood test that measures two specific markers:
- Free beta-hCG
- PAPP-A (Pregnancy-associated plasma protein A)
These results are combined with NT (Nuchal Translucency) ultrasound findings to assess the risk of Down syndrome (Trisomy 21) and other chromosomal abnormalities.
Accuracy
- Sensitivity: ~80-85%
- Can have higher false positive rates
Not a definitive test, only gives a risk ratio
What is NIPT (Non-Invasive Prenatal Testing)?
NIPT is a more advanced blood test that analyzes fragments of fetal DNA (cell-free DNA) in the mother’s blood. It can be done from as early as 10 weeks of pregnancy.
NIPT screens for:
- Trisomy 21 (Down syndrome)
- Trisomy 18 (Edwards syndrome)
- Trisomy 13 (Patau syndrome)
- Sex chromosome conditions (e.g., Turner syndrome)
- Microdeletions (depending on the panel)
Accuracy
- Sensitivity: >99% for Down syndrome
- Very low false positives
- Can also reveal fetal sex (optional)
NIPT vs. Double Marker – A Side-by-Side Comparison
| Feature | Double Marker Test | NIPT (Non-Invasive Prenatal Test) |
|---|---|---|
| Timing | 11–14 weeks | From 10 weeks onward |
| Sample Type | Blood + Ultrasound | Only Blood |
| Accuracy for Down Syndrome | ~80–85% | >99% |
| False Positive Rate | High | Very Low |
| Detection of Other Conditions | Limited | Broader scope including sex chromosome anomalies |
| Invasiveness | Non-invasive | Non-invasive |
| Follow-up Requirement | Often followed by NIPT or invasive test | Invasive test only if NIPT is positive |
| Availability | Widely available | Available at NM Medical with home collection option |
So, Which Test is Better – NIPT or Double Marker?
Choose NIPT if:
- You want higher accuracy and fewer false alarms
- You’re 35 or older, have a family history of genetic conditions, or had an abnormal scan
- You prefer to avoid further invasive testing unless absolutely necessary
Choose Double Marker if:
- You are undergoing routine first-trimester screening
- Your doctor recommends it based on NT scan results
- You’re in a low-risk category and prefer standard testing first
At NM Medical, we often recommend starting with the Double Marker Test, and if results are unclear or high-risk, NIPT is suggested as a follow-up due to its high accuracy.
Why NM Medical for NIPT & Double Marker Test?
- NABL-accredited labs with ultra-precise testing protocols
- Experienced radiologists for NT scans
- One-stop solution for Double Marker + NT scan + NIPT
- Fast TAT, genetic counseling, and home sample collection
- Available in Mumbai, Bangalore, Pune, and Nashik
Common Questions About NIPT vs. Double Marker
Can I skip Double Marker and go directly for NIPT?
Yes. Many expecting mothers opt directly for NIPT due to its higher accuracy, especially in high-risk pregnancies.
Is NIPT better than the Double Marker test?
NIPT offers superior accuracy and fewer false positives, but it’s more expensive. Your doctor may guide based on your risk category.
Is NIPT covered in insurance?
Some insurance plans cover it under maternal health or genetic testing. NM Medical offers affordable pricing and can assist with documentation.
Book Your Test Today
Whether you’re looking for a Double Marker Test or NIPT in Bangalore, Mumbai, Pune, or Nashik, NM Medical offers safe, accurate, and expert-led testing services.
- Walk-in or opt for home blood collection
- Includes genetic counseling and expert follow-up
